Therapeutic use of human growth hormone.
نویسنده
چکیده
منابع مشابه
Papillary Carcinoma of Thyroid Gland in a Patient Treated with Recombinant Growth Hormone
The first successful treatment of growth hormone (GH) deficient children with GH extracted from human pituitary was introduced during late 1950's. The subsequent availability and use of recombinant GH (rhGH) for different clinical conditions raised the question of whether this new therapeutic modality increases the risk of certain conditions such as leukemia or malignancy. Herein, we report o...
متن کاملپگیلاسیون هورمون رشد انسانی توسط پلی اتیلن گلیکول متوکسی سوکسینیمیدیل کربنات و بررسی نیمه عمر و پایداری آن
Background: Human growth hormone (hGH) use is increasing due to its important biological functions and therapeutic applications, the use of growth hormone for the treatment of obesity, short stature, burns and the importance of this hormone for athletes. Nowadays, the short half-life of hGH is a major challenge associated with the usage of this drug in the world. PEGylation is an effective appr...
متن کاملP-66: Optimization of Human Luteinizing Hormone Expression in CHO Cells Culture by Stepwise Reduction in Serum Concentration
Background: Mammalian Cell lines are the main expression system for the production of recombinant therapeutic proteins. Optimization of cell culture condition is performed via alteration in different parameter. Cell culture media plays an important role in cell cycle because of compounds such as amino acids, vitamins, inorganic salts, glucose, and serum as a source of growth factors, trace elem...
متن کاملPurification of Large Quantities of Biologically Active Recombinant Human Growth Hormone
Production and purification of human growth hormone using a simple method was studied in two recombinantEscherichia coli, D7-5 and C27-2 strains. The r-hGH was expressed in the form of inclusion body in a batchfermentation process and purified to 99% purity using a procedure based on acid precipitation of the hostderived proteins and other impurities. The effect of the pH and ...
متن کاملThe Over-Expression of Biologically Active Human Growth Hormone in a T5-Based System in Escherichia coli, Studying Temperature Effect
We studied the expression of human growth hormone (hGH) in E. coli under a bacteriophage T5-base promoter in a pQE30 expression vector. For an efficient expression of hGH cDNA, a number of codons at the hGH N-terminal coding region were altered based on the E. coli major codons. An over-expression of hGH in the bacteria, carrying the recombinant plasmids, was observed at 37°C in the presence of...
متن کاملTherapeutic Effects of Recombinant Growth Hormone in Improving the Growth of Thalassemia Major Patients: A Retrospective Study
Background and purpose: Beta thalassemia major is one of the most common inherited blood diseases and patients with this condition require regular blood transfusions. The resulting iron overload deposition causes endocrine gland disorders, including growth hormone (GH) abnormality. In this study, we examined the effects of recombinant growth hormone (rGH) in these patients. Materials and metho...
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ورودعنوان ژورنال:
- Journal of clinical pathology. Supplement
دوره 7 شماره
صفحات -
تاریخ انتشار 1976